Best Baby Formulas of 2022: 0-6 Months and 6-12 Months

Why another best baby formula article? We have trawled through various best baby formula guides and found information on the internet to be overwhelming with different guides providing different recommendations. We analysed the reviews, Google search results, Amazon Best Sellers, best baby formula guides and milk powder comparison information available on blogs and forums, and shortlisted the best for you. 

When you’re deciding which is the best milk powder for your baby, you will need to take several factors into consideration. Think about her health and dietary needs, her age, and the cost and preparation time of different formula milks, type your pediatrician recommends and your baby's reaction to the formula. 

The good news is that all formula is heavily regulated by the Food and Drug Administration and has to meet the same basic nutritional requirements. Formula is designed to mimic breast milk, but ingredients can differ. For the full lowdown on formula ingredients, review the information on choosing a formula by the AAP (American Academy of Pediatrics).

Best Baby Formula USA 2021

There are many different brands for baby or infant milk formulas in USA. We have trawled through the reviews, Google search results, Amazon Best Sellers and milk powder comparison information available on blogs and forums, and shortlisted the best for you.

Here are the best baby milk powders you can buy online in USA today.

Best Baby Formula 2021 (Summary)

  • Best Overall Baby Formula: Similac Pro-Advance Infant Formula with 2'-FL Human Milk Oligosaccharide (HMO) for Immune Support | Check Price on Amazon
  • Enfamil NeuroPro Baby Formula, Brain and Immune Support with DHA, Iron and Prebiotics, Infant formula | Check Price on Amazon
  • Similac Pro-Advance Non-GMO Infant Formula with Iron | Check Price on Amazon
  • Best Baby Formula Most Like Breast Milk: Enfamil NeuroPro Gentlease Baby Formula | Check Price on Amazon
  • Best Baby Formula to Prevent Gas: Similac Pro-Sensitive Non-GMO Infant Formula with Iron, with 2’-FL HMO, for Immune Support | Check Price on Amazon
  • Best Organic Baby Formula: Earth's Best Organic Dairy Infant Powder Formula with Iron, Omega-3 DHA and Omega-6 ARA | Check Price on Amazon

1. Best Overall Baby Formula: Similac Pro-Advance Infant Formula with 2'-FL Human Milk Oligosaccharide (HMO) for Immune Support (1.29 lb)



Similac Pro-Advance Infant Formula with 2'-FL Human Milk Oligosaccharide (HMO) for Immune Support, 23.2 ounces > Check Price on Amazon

This Similac baby milk formula has more than 7,000 customer reviews (4.8 out of 5 rating) and is the no. 4 best seller in the powder baby formula category of Amazon Best Sellers. 

This baby formula is designed for babies from 0-6 months and 6-12 months old.

Featured as 'Best overall baby formula' by Babylist:

This one covers all the basic considerations. It’s made with something called 2’-FL Human Milk Oligosaccharide—HMO for short—an immune-system nourishing prebiotic similar to one found in breast milk. (HMO is important because it feeds good bacteria to the gut, where the majority of the immune system exists.) There’s also nutrients that support brain development, eye health and developing cells. Similac Pro-Advance is also non-GMO and contains no artificial growth hormones.

Similac is also the #1 brand of baby formula chosen by hospitals, so there’s a good chance that if you’re using formula from day one (or even just supplementing), the hospital where you deliver may have some samples to help get you started.


More about the baby milk formula
  • #1 BRAND FOR IMMUNE SUPPORT*: Similac Pro-Advance is the first infant formula with 2’- FL HMO** designed to be closer than over to breast milk. (*IQVIA ProVoice Survey 12 months ending February 2020; **not from human milk)
  • NO ARTIFICIAL GROWTH HORMONES: Similac is the first leading infant formula brand with no artificial growth hormones (No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows)
  • REDUCED FUSSINESS: Parents reported reduced fussiness, gassiness, and spit-up after 1 day (After switching to Similac Pro-Advance)
  • TRUSTED: Similac is the #1 infant formula brand chosen by moms* and the #1 brand fed in hospitals (*total US infant formula all outlets as of 3/31/18, Nielsen data)
  • BRAIN & EYE DEVELOPMENT: Our exclusive blend of DHA, Lutein, and Vitamin E – nutrients also found in breast milk – helps support baby’s overall growth and brain and eye development

2. Best Overall Baby Formula: Similac Pro-Advance Infant Formula with 2'-FL Human Milk Oligosaccharide (HMO) for Immune Support (2.25 lb x 3 cans)



Similac Pro-Advance Infant Formula with 2'-FL Human Milk Oligosaccharide (HMO) for Immune Support, 36 ounces x 3 > Check Price on Amazon

The Similac pro advance is also available for bulk size purchase value offer with a package of 3 cans of the 2.25 lb but with 'over 50% more' as printed on the top of the cans.

This Similac baby milk formula has more than 6,000 customer reviews (4.8 out of 5 rating) and is the no. 1 best seller in the powder baby formula category of Amazon Best Sellers. 

Similac has one of the widest range of milk powders in USA. Similac Pro-Advance is their closest formula to breast milk. This baby milk formula is a well-formulated baby formula with 2’-FL human milk oligosaccharide that provides immune support to the baby by encouraging immune cells to release protective proteins in amounts more like the breastfed baby.

This baby Milk formula for 0-6 Months and 6-12 months baby is also one of the leading infant formula with no artificial growth hormones.

What is the difference between Similac Pro-Advance vs other formula types?


3. Enfamil NeuroPro Baby Formula, Brain and Immune Support with DHA, Iron and Prebiotics, Infant formula

The Enfamil NeuroPro baby formula has more than 5,000 customer reviews (4.8 out of 5 rating) and is the no. 2 best seller in the powder baby formula category of Amazon Best Sellers.


Enfamil NeuroPro Baby Formula, Brain and Immune Support with DHA, Iron and Prebiotics, Infant formula Inspired by Breast Milk, Non-GMO, Reusable Tub, 20.7 Oz > Check Price on Amazon

More about the baby milk formula
  • MFGM and DHA - NeuroPro is the only formula that has a fat-protein blend of MFGM and DHA, previously only found in breast milk
  • BRAIN-BUILDING NUTRITION - Get brain building nutrition inspired by breast milk from Enfamil
  • SUPPORT FOR YOUR INFANT - Complete nutrition for babies through 12 months, easy-to-digest proteins and dual prebiotics for immune health
  • No.1 PEDIATRICIAN RECOMMENDED INFANT FORMULA - The No.1 trusted brand for brain-building & immune support
  • SNAP ELIGIBLE - Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits

4. Best Baby Formula Most Like Breast Milk: Enfamil NeuroPro Gentlease Baby Formula

The Enfamil NeuroPro Gentlease baby formula has more than 2,500 customer reviews and is the no. 2 best seller in the powder baby formula category of Amazon Best Sellers.
Enfamil NeuroPro Gentlease Baby Formula Milk Powder, 19.5 Ounce > Check Price on Amazon

Featured as 'Best Baby Formula Most Like Breast Milk' by Babylist:

Enfamil’s Neuro-Pro line is backed by years of research on breast milk and clinical studies around its brain-building nutritional qualities. The formula is the only one to contain milk fat globule membrane (MFGM), a 3-layered membrane previously found only in breast milk and that’s been proven to support brain development. Neuro-Pro also contains DHA, proteins and baby probiotics for immune support. Parents love the gentle formula that helps reduce fussiness, colic and gas.
Keep in Mind

If a sensitive belly isn’t an issue, the brand also makes a standard Enfamil Neuro-Pro formula, as well as the Enspire line, the first and only formula to contain MFGM and Lactoferrin (two components of breast milk that support brain and immune development).

More about the baby milk formula
  • Emerging evidence from a recent clinical study showed MFGM in formula supports cognitive development similar to breast milk
  • #1 trusted brand for brain-building & immune support
  • Get brain building nutrition inspired by breast milk from the formula brand that's #1 recommended by Pediatricians
  • For easing fussiness, gas and crying within 24 hours
  • The only formula that has a fat-protein blend of MFGM and DHA, previously only found in breast milk
  • Complete nutrition for babies through 12 months, easy-to-digest proteins and dual prebiotics for immune health

5. Best Baby Formula to Prevent Gas: Similac Pro-Sensitive Non-GMO Infant Formula with Iron, with 2’-FL HMO, for Immune Support

Another Similac baby milk formula best seller with more than 2,200 customer reviews and is currently the no. 6 best seller in the powder baby formula category of Amazon Best Sellers. 



Similac Pro-Sensitive Non-GMO Infant Formula with Iron, with 2’-FL HMO, for Immune Support, Baby Formula, Powder, 2.18 Lb (Pack of 3) (One-Month Supply) Check Price on Amazon

Description about the baby milk formula
  • Similac Pro-Sensitive is the first infant formula for sensitive tummies with 2’-FL HMO;(Based on Pediatrician Recommendations and IQVIA ProVoice Survey 12 months ending February 2020; not from human milk)
  • VALUE SIZE/SUBSCRIBE and SAVE: 1 Can provides 55% more powder than the 1.41-lb container; 3 cans provide a one-month supply or 189 4-fl-oz bottles; Choose Subscribe and Save for additional savings and convenience
  • FOR SENSITIVE TUMMIES: Designed for fussiness and gas due to lactose sensitivity; Not for infants or children with galactosemia
  • IMMUNE SUPPORT: Similac Pro-Sensitive is the first infant formula with 2’-FL human milk oligosaccharide (Not from human milk)
  • TRUSTED: Similac is the No.1 infant formula brand chosen by moms and the No.1 brand fed in hospitals (total US infant formula all outlets as of 3/31/18, Nielsen data)
  • OptiGRO: Our exclusive blend of DHA, Lutein, and Vitamin E, nutrients also found in breast milk, help support baby’s brain and eye development
  • Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits
  • In select stores; The SNAP (Supplemental Nutrition Assurance Program) name is a service mark of the U.S. Department of Agriculture;USDA does not endorse any goods, services, or enterprises

6. Best Organic Baby Formula: Earth's Best Organic Dairy Infant Powder Formula with Iron, Omega-3 DHA and Omega-6 ARA

This organic baby milk formula has more than 2,000 customer reviews and is the no. 10 best seller in the powder baby formula category of Amazon Best Sellers. 


Earth's Best Organic Dairy Infant Powder Formula with Iron, Omega-3 DHA and Omega-6 ARA, 23.2 oz > Check Price on Amazon

Description about the baby milk formula
  • Organic formula that is easy to digest and nutritionally complete for baby's first twelve months
  • All lactose milk based powder formulation; our closest formula to breast milk, no added corn syrup solids
  • Omega 3 DHA and Omega 6 ARA fatty acids naturally found in breast milk to support brain and eye development, Iron for healthy development
  • With Lutein for Eyes and Prebiotic Fructo-oligosaccharides for Immunity
  • Non-GMO ingredients and Kosher; Made without prohibited synthetic pesticides and fertilizers. No artificial growth hormones


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